In eukaryotes the presence of the dimeric phospholipid cardiolipin (CL) is limited to the mitochondrial membranes. It resides predominantly in the inner membrane where it interacts with components of the mitochondrial electron transfer chain. CL …
Objective: In this study, we present a simultaneous inference procedure as a unified analysis framework for genetic association studies. Methods: The method is based on the formulation of multiple marginal models that reflect different modes of …
The isolation, structure elucidation, and synthesis of antalid (1), a novel secondary metabolite from Polyangium sp., is described herein. The structure elucidation of 1 was performed with the aid of mass spectrometry, high field NMR experiments, and …
Two or higher-order factorial designs are very common in agricultural and horticultural experiments. The evaluation of such trials by analysis of variance (anova) and the corresponding F-tests for the interaction effects covers only a global decision …
In toxicological studies interest often lies in proportions or counts for which an increase in the dose group over control indicates a safety risk. Additionally, the control group observes values that are zero or near-to-zero for endpoints …
Testing for or against a qualitative interaction is relevant in randomized clinical trials that use a common primary factor treatment and have a secondary factor, such as the centre, region, subgroup, gender or biomarker. Interaction contrasts are …
This study considers the detection of treatment-by-subset interactions in a stratified, randomised clinical trial with a binary-response variable. The focus lies on the detection of qualitative interactions. In addition, the presented method is …
Profile hidden Markov models (HMMs) were used to predict the configuration of secondary alcohols and α-methyl branches of modular polyketides. Based on the configurations of two chiral centers in these polyketides, 78 ketoreductases were classified …
In a typical toxicity bioassay, an untreated control group and several groups of increasing dosage are studied. The use of historical control data from previous trials provides additional information for statistical analysis. It is assumed that …