multi-regional clinical trials | AKitsche Bloghttps://akitsche.netlify.app/tag/multi-regional-clinical-trials/multi-regional clinical trialsWowchemy (https://wowchemy.com)en-us© 2021 Andreas KitscheWed, 27 Apr 2016 00:00:00 +0000https://akitsche.netlify.app/images/icon_hufdd866d90d76849587aac6fbf27da1ac_464_512x512_fill_lanczos_center_2.pngmulti-regional clinical trialshttps://akitsche.netlify.app/tag/multi-regional-clinical-trials/Power and sample size computations for the simultaneous assessment of the consistency of treatment effectshttps://akitsche.netlify.app/project/power_consistency/Wed, 27 Apr 2016 00:00:00 +0000https://akitsche.netlify.app/project/power_consistency/<p>In this study power and sample size calculations for the analysis of treatment-by-subgroup interactions are proposed. Therefore, the interaction effect is either defined via product-type interaction contrasts or as ratio of treatment differences. The latter formulation allows besides the detection of interactions also the assessment of the consistency/heterogeneity of the subgroup-specific treatment effect by the definition of an inconsistency margin.</p> <p>You can find the pdf of a detailed article <a href="pdf/PowerConsistency_SIM.pdf">here</a>. Furthermore, the slides from a corresponding talk are given <a href="JournalClub_Power.pdf">here</a>.</p>